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. 1984 Mar;25(3):310-2.

Synthesis of cyclopentano-N-methylphosphatidylethanolamines: Aminolysis During the Use of Methylamine

  • PMID: 6726084
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Synthesis of cyclopentano-N-methylphosphatidylethanolamines: Aminolysis During the Use of Methylamine

H Pajouhesh et al. J Lipid Res. .
Free article

Abstract

Monomethylamine and N-benzyl-N-methylamine were used as nucleophiles in the amination of the bromoethylester of cyclopentano-phosphatidic acid. The former reagent led to extensive aminolysis and the quantitative formation of N-methylpalmitamide, rather than the desired cyclopentano-phosphatidyl-N-methylethanolamine. However, the method of Shapiro and Rabinsohn (1964. Biochemistry. 3:603-605), in which N-benzyl-N-methylamine was used as a nucleophile, was adapted for a successful synthesis.

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