Recent human influenza A (H1N1) viruses are closely related genetically to strains isolated in 1950

Nature. 1978 Jul 27;274(5669):334-9. doi: 10.1038/274334a0.


Comparison of the oligonucleotide maps of the RNAs of current human influenza (H1N1) virus isolates shows these strains to be much more closely related to viruses isolated in 1950 than to strains which circulated before or after that period.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Genetic Variation
  • Hemagglutinins, Viral / analysis
  • Humans
  • Influenza A Virus, H1N1 Subtype*
  • Influenza A virus / genetics*
  • Influenza A virus / immunology
  • Influenza, Human / microbiology*
  • Neuraminidase / immunology
  • RNA, Viral / genetics*


  • Hemagglutinins, Viral
  • RNA, Viral
  • Neuraminidase