Histamine H2-binding studies in the guinea-pig brain

Agents Actions. 1984 Apr;14(3-4):543-5. doi: 10.1007/BF01973867.


Using 3H-mepyramine and 3H-tiotidine to label, respectively, the histamine H1- and H2-receptors, we have assessed the distribution of these receptors in five distinct areas of guinea-pig brain. With regard to the H2-receptor, we could detect no binding in either the cerebellum or pons-medulla, whereas the distribution in the other brain areas was corpus striatum greater than cortex greater than hippocampus. This was in contrast to the distribution of the H1-receptor which was found to be in all areas studied but predominantly in the cerebellum.

MeSH terms

  • Animals
  • Brain Chemistry*
  • Cimetidine / analogs & derivatives
  • Cimetidine / metabolism
  • Female
  • Guinea Pigs
  • Male
  • Pyrilamine / metabolism
  • Radioligand Assay
  • Receptors, Histamine / analysis*
  • Receptors, Histamine H2 / analysis*
  • Tritium


  • Receptors, Histamine
  • Receptors, Histamine H2
  • Tritium
  • Cimetidine
  • tiotidine
  • Pyrilamine