Treatment of xerophthalmia with retinol, tretinoin, and etretinate

Arch Ophthalmol. 1984 Jun;102(6):926-7. doi: 10.1001/archopht.1984.01040030746036.


Topical retinol, tretinoin (all-trans-retinoic acid) and etretinate (a synthetic retinoid) were used in rabbits to treat experimental xerophthalmia due to vitamin A deficiency. Both 0.2% retinol and 0.1% and 0.2% tretinoin effectively reversed abnormal corneal epithelial keratinization within one to two days and restored corneal clarity within two to four days following topical application three times per day. Etretinate was ineffective in the concentration used (0.2%). In addition, application of tretinoin to one eye effectively reversed xerophthalmic changes in the other eye. Retinol did not have an effect on the other eye.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Topical
  • Animals
  • Drug Evaluation, Preclinical
  • Etretinate / therapeutic use
  • Rabbits
  • Retinoids / therapeutic use*
  • Tretinoin / therapeutic use
  • Vitamin A / therapeutic use
  • Xerophthalmia / drug therapy*


  • Retinoids
  • Vitamin A
  • Tretinoin
  • Etretinate