Sinus histiocytosis with massive lymphadenopathy: response to cyclophosphamide therapy

Cancer Treat Rep. 1984 Jun;68(6):901-2.

Abstract

A patient with sinus histiocytosis with massive lymphadenopathy is described. After attempts to control lymph node size and constitutional symptoms with corticosteroids were unsuccessful with radiation therapy and nonsteroidal anti-inflammatory drugs, the patient was treated with two courses of low doses of oral cyclophosphamide therapy. He remains in complete remission 15 months after therapy was discontinued.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biopsy
  • Bone Marrow / pathology
  • Cyclophosphamide / therapeutic use*
  • Humans
  • Lymph Nodes / drug effects
  • Lymph Nodes / pathology
  • Lymphatic Diseases / drug therapy*
  • Lymphatic Diseases / pathology
  • Male
  • Neck

Substances

  • Cyclophosphamide