Carcinogenicity in mice of a mutagenic compound, 2-amino-3-methylimidazo[4,5-f]quinoline, from broiled sardine, cooked beef and beef extract

Carcinogenesis. 1984 Jul;5(7):921-4. doi: 10.1093/carcin/5.7.921.

Abstract

A potent mutagenic compound, 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ), isolated from broiled sardines, cooked beef and beef extract was tested for carcinogenicity in CDF1 mice of both sexes. Mice were given diet containing 0.03% IQ or control diet for up to 675 days. Tumors were observed mainly in the liver, forestomach and lung. In the mice given IQ, the incidences of these tumors were as follows: liver tumors - 41% in males and 75% in females; tumors of the forestomach - 41% in males and 31% in females; lung tumors - 69% in males and 42% in females. In the control mice, incidences of these tumors were as follows: liver tumors - 9% in males and 8% in females; tumors of the forestomach - 3% in males and 0% in females; lung tumors - 21% in males and 18% in females. The incidences of tumors in the liver, forestomach and lung were significantly higher in mice given IQ than in control mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cattle
  • Female
  • Fishes*
  • Food Analysis
  • Hot Temperature
  • Liver Neoplasms / chemically induced
  • Lung Neoplasms / chemically induced
  • Male
  • Meat* / analysis
  • Mice
  • Mice, Inbred Strains
  • Mutagens*
  • Neoplasms, Experimental / chemically induced*
  • Quinolines / toxicity*
  • Stomach Neoplasms / chemically induced

Substances

  • Mutagens
  • Quinolines
  • 2-amino-3-methylimidazo(4,5-f)quinoline