Rapid onset of an increase in caffeine residence time in young women due to oral contraceptive steroids

Eur J Clin Pharmacol. 1984;26(3):371-3. doi: 10.1007/BF00548769.

Abstract

Oral contraceptive steroids increased the residence time of caffeine in 9 young women by a factor of 2. The effect was already manifested during the first cycle 2 weeks after starting oral contraceptive steroids (OCS) and was slightly increased in the second cycle, after 6 weeks on OCS. Toxic effects attributed to oral contraceptive steroids may in part be indirect and due to prolonged retention of absorbed toxic agents to which women are exposed.

PIP: Oral contraceptives (OCs) increased the residence time of caffeine in 9 young women by a factor of 2. The effect was already manifested during the 1st cycle 2 weeks after beginning OCs and was slightly increased in the 2nd cycle, after 6 weeks on OCs. Toxic effects attributed to OCs may in part be indirect and due to prolonged retention of absorbed toxic agents to which women are exposed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Caffeine / blood*
  • Contraceptives, Oral / adverse effects*
  • Contraceptives, Oral, Hormonal / adverse effects*
  • Female
  • Half-Life
  • Humans
  • Kinetics

Substances

  • Contraceptives, Oral
  • Contraceptives, Oral, Hormonal
  • Caffeine