In vitro stability of sodium nitroprusside solutions for intravenous administration

J Pharm Sci. 1984 Jun;73(6):838-9. doi: 10.1002/jps.2600730636.


A sensitive high-performance liquid chromatographic assay for nitroprusside using an ion-exchange column and UV detection was developed to evaluate the stability of aqueous solutions of sodium nitroprusside in light-protected glass and plastic containers and during simulated infusions. The results showed that sodium nitroprusside is stable in 5% dextrose, normal saline, and lactated Ringer's solutions in light-protected glass or plastic containers. In addition, there was no decrease in the delivered potency of sodium nitroprusside solutions during simulated infusions lasting up to 24 h.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromatography, High Pressure Liquid / methods
  • Drug Packaging
  • Drug Stability
  • Ferricyanides / analysis*
  • Infusions, Parenteral
  • Nitroprusside / analysis*
  • Solutions
  • Spectrophotometry, Ultraviolet / methods
  • Time Factors


  • Ferricyanides
  • Solutions
  • Nitroprusside