Persistence of pneumococcal antibodies after immunization in patients with systemic lupus erythematosus

J Rheumatol. 1984 Jun;11(3):306-8.


Antibody levels to 12 different pneumococcal capsular polysaccharides as well as the combined mean antibody level were measured in 19 patients with systemic lupus erythematosus (SLE) at 1, 2 and 3 years after immunization with a polyvalent pneumococcal vaccine and compared to 5 normal control subjects immunized at the same time. The mean levels in the 19 SLE patients were lower in all 3 years but the difference reached significance only in Year 1. At 3 years, 8 of the 19 SLE patients had levels below that considered to be protective and one such patient developed a pneumococcal pneumonia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibodies, Bacterial / analysis*
  • Bacterial Vaccines / therapeutic use
  • Humans
  • Immunization
  • Lupus Erythematosus, Systemic / immunology*
  • Polysaccharides, Bacterial / immunology
  • Streptococcus pneumoniae / immunology*
  • Time Factors


  • Antibodies, Bacterial
  • Bacterial Vaccines
  • Polysaccharides, Bacterial