On the cause of raised serum-amylase in diabetic ketoacidosis

Lancet. 1977 Apr 30;1(8018):929-31. doi: 10.1016/s0140-6736(77)92225-5.

Abstract

7 of 13 patients with diabetic ketoacidosis had raised serum-amylase concentrations. Isoenzymes analysis by polyacrylamide-gel electrophoresis showed that salivary-type amylases and not pancreatic-type amylases were responsible for the rise in 6 or the 7 cases. This demonstrates that the pancreas is usually not the origin of the increase in serum-amylase. Since salivary-type amylases are widely distributed in glandular epithelium, it is suggested that hyperamylasaemia in diabetic ketoacidosis is most often caused by systemic derangement of carbohydrate metabolism.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Amylases / blood*
  • Blood Glucose / analysis
  • Carbon Dioxide / blood
  • Creatinine / blood
  • Diabetic Ketoacidosis / enzymology*
  • Electrophoresis, Polyacrylamide Gel
  • Female
  • Humans
  • Hydrogen-Ion Concentration
  • Isoenzymes / blood*
  • Keto Acids
  • Ketones / blood
  • Male
  • Middle Aged
  • Pancreatic Juice / enzymology
  • Saliva / enzymology

Substances

  • Blood Glucose
  • Isoenzymes
  • Keto Acids
  • Ketones
  • Carbon Dioxide
  • Creatinine
  • Amylases