Stability of fluorouracil in plastic containers used for continuous infusion at home

Am J Hosp Pharm. 1984 Jun;41(6):1153-6.

Abstract

The stability of fluorouracil when prepared and stored in plastic containers used for continuous infusion in home therapy was studied. Fluorouracil was diluted with 5% dextrose injection. Samples were stored for 16 weeks at 5 degrees C and room temperature in polyvinyl chloride drug reservoirs and at 5 degrees C in elastomeric balloons used in a disposable drug pump. Periodically, samples were tested by a stability-indicating high-performance liquid chromatography (HPLC) assay. At 5 degrees C, there was no significant degradation. At room temperature, there was a progressive increase in fluorouracil concentration, presumably because of evaporation of water. A 10% change in the fluorouracil concentration over 55 days was predicted. Fluorouracil is stable in 5% dextrose injection for at least 16 weeks when stored at 5 degrees C in the two types of containers studied.

MeSH terms

  • Bromouracil / analysis
  • Chromatography, High Pressure Liquid
  • Drug Packaging
  • Drug Stability
  • Fluorouracil* / administration & dosage
  • Fluorouracil* / analysis
  • Home Care Services
  • Hot Temperature
  • Infusions, Parenteral
  • Plastics
  • Spectrophotometry, Ultraviolet
  • Time Factors

Substances

  • Plastics
  • Bromouracil
  • Fluorouracil