The effect of d-timolol on intraocular pressure in patients with ocular hypertension

Am J Ophthalmol. 1984 Jul 15;98(1):73-8. doi: 10.1016/0002-9394(84)90191-0.


The stereoisomer form of timolol used in the treatment of glaucoma is l-timolol. Although d-timolol is a less potent beta-adrenergic receptor blocker than l-timolol, several laboratory studies have found that d-timolol has ocular hypotensive effects. Thus, d-timolol may be a useful therapeutic agent for glaucoma that has fewer systemic side effects than l-timolol. We conducted a randomized, double-masked, single-drop study of the effects of d-timolol and placebo on intraocular pressure in 34 patients with ocular hypertension. d-Timolol significantly lowered intraocular pressure for the six-hour duration of the study. No patients receiving the drug reported subjective side effects. There was no change in visual acuity, pupil size, or results of external ocular or slit-lamp examinations during the study. No changes in pulse rate or blood pressure were attributable to the drug.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Topical
  • Adult
  • Aged
  • Blood Pressure / drug effects
  • Double-Blind Method
  • Drug Evaluation
  • Eye / drug effects
  • Female
  • Heart Rate / drug effects
  • Humans
  • Intraocular Pressure / drug effects*
  • Male
  • Middle Aged
  • Ocular Hypertension / drug therapy*
  • Ophthalmic Solutions
  • Pupil / drug effects
  • Random Allocation
  • Stereoisomerism
  • Timolol / administration & dosage
  • Timolol / therapeutic use*
  • Visual Acuity / drug effects


  • Ophthalmic Solutions
  • Timolol