"Locked-in" state following Reye's syndrome

Ann Neurol. 1984 Jun;15(6):599-601. doi: 10.1002/ana.410150614.


A 12-year-old boy with Reye's syndrome had an initial course complicated by increased intracranial pressure and systemic hypotension. He subsequently developed brainstem damage producing permanent apnea and a "locked-in" state. Nevertheless, the normal architecture of sleep was retained, as was a high degree of intelligence.

Publication types

  • Case Reports

MeSH terms

  • Brain Stem / physiopathology
  • Child
  • Electroencephalography
  • Humans
  • Intelligence
  • Intracranial Pressure
  • Male
  • Quadriplegia / diagnosis*
  • Quadriplegia / physiopathology
  • Reye Syndrome / diagnosis*
  • Reye Syndrome / physiopathology