Transfer of antibiotics into maternal milk

Biol Res Pregnancy Perinatol. 1984;5(2):57-60.


Thirty antibiotics, including penicillins, cephems, chloramphenicol, tetracyclines, macrolides, and aminoglycosides, were given p.o., i.m. or i.v. once to 70 puerperal women to compare milk drug levels with serum levels over a 6-h period. Antibiotic transfer into the milk was small. No drugs except for a few (chloramphenicol, tetracyclines, macrolides) reached the level of 1 mcg/ml or greater. Penicillins and cephams detected in trace amounts in the milk are likely to have little effect on infants.

MeSH terms

  • Administration, Oral
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / blood
  • Anti-Bacterial Agents / metabolism*
  • Cephalosporins / metabolism
  • Female
  • Humans
  • Injections, Intramuscular
  • Injections, Intravenous
  • Milk, Human / analysis*
  • Penicillins / metabolism
  • Postpartum Period
  • Pregnancy


  • Anti-Bacterial Agents
  • Cephalosporins
  • Penicillins