Effect of bilateral lesions of the dentate and interpositus cerebellar nuclei on conditioning of heart-rate and nictitating membrane/eyelid responses in the rabbit

Brain Res. 1984 Jul 9;305(2):323-30. doi: 10.1016/0006-8993(84)90438-4.


It has been shown that unilateral lesions of the medial dentate/lateral interpositus nuclear region of the cerebellum abolish the learned nictitating membrane (NM)/eyelid response of the eye ipsilateral to the lesion. The present study examined the effects of bilateral cerebellar lesions on acquisition of heart-rate conditioning (often viewed as a measure of 'conditioned fear') and both its short-and long-term effects on NM/eyelid learning and relearning. The results demonstrate that cerebellar lesions that completely and permanently abolish acquisition or retention of the somatic response (NM/eyelid) bilaterally have no effect on heart-rate conditioning. The neuronal circuits necessary for learning of the heart-rate response and for learning of the adaptive somatic response are thus in significant part different. Results are tentatively interpreted within the context of a two-process theory of aversive learning: an initial phase indexed by conditioned autonomic and 'non-specific' responses such as heart-rate and a subsequent phase of learning the specific adaptive responses.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Avoidance Learning / physiology*
  • Brain Mapping
  • Cerebellar Nuclei / physiology*
  • Conditioning, Classical / physiology*
  • Conditioning, Eyelid
  • Heart Rate*
  • Psychological Theory
  • Rabbits
  • Retention, Psychology / physiology