Concentrations of Ag, Al, Au, Bi, Cd, Cu, Pb, Sb, and Se in cerebrospinal fluid of patients with cerebral neoplasms

Clin Chem. 1984 Aug;30(8):1358-60.

Abstract

We measured the concentrations of nine trace elements in cerebrospinal fluid of 11 patients with malignant brain tumors, 11 with benign brain tumors, and 10 control patients, using flameless atomic absorption spectrophotometry. The mean and standard deviation for these concentrations (microgram/L) in the control group were 5.1 +/- 2.9 (silver), 326.6 +/- 171.2 (aluminum), 38.5 +/- 32.2 (gold), 36.6 +/- 23.7 (bismuth), 1.5 +/- 1.3 (cadmium), 39.8 +/- 24.7 (copper), 15.7 +/- 11.5 (lead), 20.9 +/- 3.8 (antimony), and 19.1 +/- 13.3 (selenium). Concentrations of silver and lead were markedly increased in patients with malignant cerebral neoplasms. The malignant-tumor/control patient concentration ratios were 2.31 for silver and 2.11 for lead. We observed no significant differences between the results for the benign tumor patients and the control group.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Astrocytoma / cerebrospinal fluid
  • Brain Neoplasms / cerebrospinal fluid*
  • Brain Neoplasms / surgery
  • Child
  • Chondrosarcoma / cerebrospinal fluid
  • Craniopharyngioma / cerebrospinal fluid
  • Female
  • Humans
  • Male
  • Medulloblastoma / cerebrospinal fluid
  • Meningioma / cerebrospinal fluid
  • Metals / cerebrospinal fluid*
  • Middle Aged
  • Pinealoma / cerebrospinal fluid
  • Selenium / cerebrospinal fluid*
  • Spectrophotometry, Atomic

Substances

  • Metals
  • Selenium