Hb Okazaki [beta 93(F8) Cys----Arg], a new hemoglobin variant with increased oxygen affinity and instability

K Harano; T Harano; S Shibata; S Ueda; H Mori; M Seki

doi:10.1016/0014-5793(84)81014-5

Hb Okazaki [beta 93(F8) Cys----Arg], a new hemoglobin variant with increased oxygen affinity and instability

FEBS Lett. 1984 Jul 23;173(1):45-7. doi: 10.1016/0014-5793(84)81014-5.

Authors

K Harano, T Harano, S Shibata, S Ueda, H Mori, M Seki

PMID: 6745435
DOI: 10.1016/0014-5793(84)81014-5

Abstract

A new abnormal hemoglobin, Hb Okazaki [beta 93(F9) Cys----Arg], with an amino acid substitution at the tyrosine pocket of the beta chain as well as at the alpha 2 beta 1 contact of the quaternary structure of molecule, was discovered in a Japanese man. This hemoglobin showed increased oxygen affinity and molecular instability.

MeSH terms

Amino Acid Sequence
Hemoglobins, Abnormal / metabolism*
Humans
Isoelectric Point
Oxyhemoglobins*
Peptide Fragments / analysis
Structure-Activity Relationship

Substances

Hemoglobins, Abnormal
Oxyhemoglobins
Peptide Fragments