Studies of the Mouse Ly-6 Alloantigen System. II. Complexities of the Ly-6 Region

Immunogenetics. 1984;20(1):47-56. doi: 10.1007/BF00373446.


The discovery of several monoclonal antibodies provided the impetus to revisit the Ly-6 group of antigens. Our serological data point to the existence of at least five separate Ly-6 antigens. They are distinguished by the patterns of their tissue expression as (1) the classical Ly-6 alloantigen of peripheral lymphocytes (Ly-m6.2A), (2) a bone marrow cell-restricted antigen (Ly-m6.2B), (3) an antigen shared by bone marrow cells and peripheral lymphocytes (Ly-m6.2C, possibly identical with H9/25), (4) an antigen expressed on bone marrow cells, thymocytes, and peripheral lymphocytes (Ly-m6.2D), and (5) an antigen occurring exclusively on lymphoblasts (Ly-m6.1E, similar to Ala-1). ThB is a sixth distinct antigen of the group. The assumption that separate antigens exist is supported by distinctive distribution patterns in normal and neoplastic tissues. The genes controlling Ly-6 antigens are closely linked, as they are transmitted as two haplotypes only. One incidence of a crossover within the Ly-6 region was observed: the Ly-6B.2 alloantigen was expressed in NZB mice, which type Ly-6.1 for other Ly-6 specificities.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology
  • Antigens, Ly / genetics*
  • Antigens, Ly / immunology
  • Cell Line
  • Cell Membrane / immunology
  • Cell Membrane / ultrastructure
  • Genetic Linkage
  • Mice
  • Mice, Inbred Strains / immunology*
  • Neoplasms, Experimental / immunology
  • Tissue Distribution


  • Antibodies, Monoclonal
  • Antigens, Ly