The Tromsø heart-study. High-density lipoprotein and coronary heart-disease: a prospective case-control study

Lancet. 1977 May 7;1(8019):965-8. doi: 10.1016/s0140-6736(77)92274-7.


The relationship of future clinical coronary heart-disease (C.H.D.) to the plasma-high-density-lipoprotein (H.D.L.)-cholesterol concentration has been examined in a 2-year case-control follow-up study of 6595 men aged 20-49 years living in the municipality of Tromsø, Norway. Measurements were also made of the cholesterol concentration in lower-density (i.e., density less than 1-603 g/ml) lipoproteins, plasma-triglycerides, systolic and diastolic blood-pressures, relative body-weight, and cigarette consumption. Discriminant-function analysis showed that coronary risk was inversely related to H.D.L.-cholesterol concentration and directly related to density less than 1-063 cholesterol. These relationships were independent of each other and of the other measured variables, which showed no significant differences between the cases and controls. H.D.L. cholesterol made a three-fold greater contribution to the prediction of future C.H.D. than did density less than 1-063 cholesterol in this cohort of young men. These findings support the proposal that a low H.D.L. concentration is a common antecedent of clinical C.H.D. and is important in accelerating the progression of coronary atherosclerosis.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Blood Pressure
  • Body Constitution
  • Cholesterol / blood
  • Clinical Trials as Topic
  • Coronary Disease / etiology*
  • Follow-Up Studies
  • Humans
  • Lipoproteins, HDL / blood*
  • Lipoproteins, LDL / blood
  • Male
  • Middle Aged
  • Norway
  • Prospective Studies
  • Risk
  • Smoking
  • Triglycerides / blood


  • Lipoproteins, HDL
  • Lipoproteins, LDL
  • Triglycerides
  • Cholesterol