Mutations in the hemagglutinin receptor-binding site can change the biological properties of an influenza virus

J Virol. 1984 Aug;51(2):567-9. doi: 10.1128/JVI.51.2.567-569.1984.

Abstract

Avian influenza virus reassortants containing human influenza virus hemagglutinins do not replicate in ducks. Two mutations in the receptor-binding site of a human hemagglutinin at residues 226 and 228 allowed replication in ducks. The mutations resulted in a receptor-binding-site sequence identical to the known avian influenza virus sequences.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • DNA Replication
  • Ducks
  • Genes, Viral
  • Humans
  • Influenza A virus / genetics*
  • Influenza A virus / immunology
  • Mutation*
  • Receptors, Immunologic / genetics*
  • Species Specificity
  • Virus Replication

Substances

  • Receptors, Immunologic