Clinical comparison of ibuprofen, fenoprofen calcium, naproxen and tolmetin sodium in rheumatoid arthritis

J Rheumatol. 1982 May-Jun;9(3):402-7.


After baseline aspirin therapy, 89 rheumatoid arthritis patients completed a double-blind, crossover trial comparing ibuprofen, fenoprofen, naproxen, and tolmetin. Initially, patients took the manufacturer's recommended starting dose; this could be increased by 50% within the first 2 weeks of therapy. Patients remained at the chosen dose for 4 weeks and then changed to the next drug. All 4 drugs were tolerated better than aspirin (p less than 0.001). There were no statistically significant differences among the 4 drugs for any efficacy measurements. However, patients' and physicians' rankings showed the same order of preferences: naproxen, ibuprofen, fenoprofen, tolmetin, and aspirin.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Anti-Inflammatory Agents / therapeutic use*
  • Arthritis, Rheumatoid / diagnosis
  • Arthritis, Rheumatoid / drug therapy*
  • Aspirin / therapeutic use
  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Fenoprofen / therapeutic use
  • Humans
  • Ibuprofen / therapeutic use
  • Male
  • Middle Aged
  • Naproxen / therapeutic use
  • Tolmetin / therapeutic use


  • Anti-Inflammatory Agents
  • Naproxen
  • Tolmetin
  • Aspirin
  • Fenoprofen
  • Ibuprofen