Enzyme studies in tardive dyskinesia. III. Noradrenergic hyperactivity in a subgroup of dyskinetic patients

J Clin Psychopharmacol. 1982 Oct;2(5):318-20.


This study was undertaken to test a hypothesis that tardive dyskinesia (TD) patients with high plasma dopamine-beta-hydroxylase (DBH) activity would also have other enzymatic alterations suggestive of noradrenergic hyperactivity. Plasma renin activity was chosen as a peripheral indicator of noradrenergic function. We measured plasma renin activity in three groups of female psychiatric inpatients over the age of 50: a TD group with high plasma DBH activity, a TD group with low plasma DBH activity, and a non-TD group. The high-DBH TD group had significantly greater plasma renin activity than the other two groups. Our results are consistent with the hypothesis that a subgroup of TD patients has relative noradrenergic hyperactivity.

MeSH terms

  • Aged
  • Blood Pressure
  • Dopamine beta-Hydroxylase / blood
  • Dyskinesia, Drug-Induced / enzymology*
  • Dyskinesia, Drug-Induced / physiopathology
  • Female
  • Humans
  • Male
  • Norepinephrine / physiology*
  • Renin / blood


  • Dopamine beta-Hydroxylase
  • Renin
  • Norepinephrine