Genetic basis of XX male syndrome and XX true hermaphroditism: evidence in the dog

Science. 1978 Aug 18;201(4356):644-6. doi: 10.1126/science.675252.

Abstract

Serological analysis of white blood cells from the members of a family of American cocker spaniels indicates that a form of abnormal sexual development, in which individuals with a female karyotype have testes or ovotestes, is caused by anomalous transmission of male-determining H-Y genes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Differentiation
  • Disorders of Sex Development / immunology
  • Disorders of Sex Development / veterinary*
  • Dog Diseases / genetics*
  • Dogs
  • Female
  • Genes
  • Genetic Linkage
  • Histocompatibility Antigens / genetics*
  • Leukocytes / immunology
  • Male
  • Ovary / growth & development
  • Testis / growth & development
  • Y Chromosome / immunology

Substances

  • Histocompatibility Antigens