A serotonin-immunoreactive fiber system in the dorsal columns of the spinal cord

Neurosci Lett. 1982 Aug 31;31(3):247-52. doi: 10.1016/0304-3940(82)90028-3.


Serotonin-immunoreactive fibers have been observed in the dorsal columns of the golden hamster spinal cord. The fibers were visualized using the PAP method which was intensified with a DAB-nickel substrate. The fibers were arranged preferentially in the mid-sagittal plane, and many were observed coursing from the dorsal columns into the dorsal gray matter. This serotonin-immunoreactive pathway may play a role in analgesia produced by dorsal column stimulation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cricetinae
  • Ganglia, Spinal / anatomy & histology*
  • Immunoenzyme Techniques
  • Mesocricetus
  • Nerve Fibers / ultrastructure
  • Neural Pathways / anatomy & histology
  • Serotonin / metabolism*
  • Spinal Cord / anatomy & histology*


  • Serotonin