Serotonin precursors in the treatment of depression

Adv Biochem Psychopharmacol. 1982:34:259-86.


5-HT precursors are used in depressions on the basis of the 5-HT hypothesis - an hypothesis which postulates that a cerebral 5-HT deficiency can play a role in the pathogenesis of depressions. This article presents a survey of the results obtained by this therapeutic strategy. There are strong indications that 5-HTP is of therapeutic value, particularly in the 5-HT-deficient subgroup of vital depressions. In the same subgroup, one controlled study has so far also shown a prophylatic 5-HTP effect. The effect of clomipramine is potentiated by 1-5-HTP, and this combination can give good results in therapy-resistant vital depressions. Other tricyclic compounds have not been studied in this context, nor have selective 5-HT reuptake inhibitors. The results of tryptophan studies are less unequivocal, possibly due to pharmacokinetic factors. Another possible explanation might be that, unlike 5-HTP research, tryptophan studies have so far disregarded the patient's serotonergic status. 5-HT research in depressions has also yielded the concept of the biochemical classifiability of depressions. This may become an important supplement to the conventional criteria of classification of depressions: symptomatology, etiology, and course.

Publication types

  • Review

MeSH terms

  • 5-Hydroxytryptophan / adverse effects
  • 5-Hydroxytryptophan / therapeutic use
  • Antidepressive Agents / therapeutic use
  • Brain Diseases / metabolism
  • Depressive Disorder / drug therapy*
  • Depressive Disorder / metabolism
  • Depressive Disorder / prevention & control
  • Humans
  • Serotonin / metabolism*
  • Serotonin / physiology
  • Tryptophan / administration & dosage
  • Tryptophan / therapeutic use


  • Antidepressive Agents
  • Serotonin
  • Tryptophan
  • 5-Hydroxytryptophan