Mutagenesis in cdc7 strains of yeast. The fate of premutational lesions induced by ultraviolet light

Mutat Res. 1982 Nov;105(5):313-8. doi: 10.1016/0165-7992(82)90099-9.


cdc7-1 cells bearing UV-revertible mutations are virtually immutable by all means so far tested. By mating UV treated cdc7-1 cells with untreated cdc7+ cells carrying the same revertible alleles it is possible to rescue premutational lesions as revertants and to study their fate in cdc7-1 cells. If storage intervenes between treatment and mating there is a rapid decline in revertants rescued. This is not related to the death of cdc7-1 cells with storage nor does it reflect a progressive loss in their ability to mate.

Publication types

  • Comparative Study

MeSH terms

  • Alleles
  • Crosses, Genetic
  • Heterozygote
  • Homozygote
  • Mutation*
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / radiation effects*
  • Species Specificity
  • Ultraviolet Rays*