Clinical relevance of antithrombin III

Semin Thromb Hemost. 1982 Oct;8(4):276-87. doi: 10.1055/s-2007-1005058.

Abstract

Many unrelated clinical conditions that are associated with significant decreases in antithrombin III have been summarized. In addition, prospects for future therapy with antithrombin III concentrates have been discussed. The clinical indications for antithrombin III determinations, including the reasons for performing the assay and those specific patient populations subjected to antithrombin III assays in this author's clinical practice, have been outlined. It is to be anticipated that with the new general availability of simple reliable antithrombin III assay systems using synthetic substrates that more and more populations will be adequately studied and clinical indications for the use of antithrombin III determinations and concentrates may become more firm or may change.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Antithrombin III / genetics
  • Antithrombin III / metabolism
  • Antithrombin III / pharmacology*
  • Blood Coagulation*
  • Contraceptives, Oral / pharmacology
  • Coronary Disease / blood
  • Coronary Disease / etiology
  • Disseminated Intravascular Coagulation / blood
  • Disseminated Intravascular Coagulation / drug therapy
  • Disseminated Intravascular Coagulation / etiology
  • Female
  • Heparin / therapeutic use
  • Humans
  • Kidney Diseases / blood
  • Kidney Diseases / etiology
  • Liver Diseases / blood
  • Liver Diseases / etiology
  • Middle Aged
  • Pulmonary Embolism / blood
  • Pulmonary Embolism / etiology
  • Syndrome
  • Thrombophlebitis / blood
  • Thrombophlebitis / etiology
  • Thrombosis / blood
  • Thrombosis / genetics

Substances

  • Contraceptives, Oral
  • Antithrombin III
  • Heparin