Human in vivo antigenic modulation induced by the anti-T cell OKT3 monoclonal antibody

Eur J Immunol. 1982 Nov;12(11):979-82. doi: 10.1002/eji.1830121116.

Abstract

The anti-pan T cell monoclonal antibody OKT3 was administered daily for 2 weeks in four human renal allograft recipients. The antibody induced a dramatic and immediate depletion of peripheral T cells followed by an in vivo antigenic modulation of the OKT3-defined membrane antigen: after three injections, OKT3-treated patients showed a limited but significant number of OKT3- cells of T cell nature (as defined by OKT4 and OKT8) which recovered the OKT3 receptor after an overnight in vitro incubation in the absence of the monoclonal antibody.

MeSH terms

  • Antibodies, Monoclonal
  • Antigens, Surface / analysis
  • Humans
  • Immune Tolerance*
  • Immunosuppression*
  • Isoantibodies
  • Kidney Transplantation
  • Kinetics
  • Membrane Proteins / immunology
  • Membrane Proteins / metabolism
  • T-Lymphocytes / immunology*

Substances

  • Antibodies, Monoclonal
  • Antigens, Surface
  • Isoantibodies
  • Membrane Proteins