Podophyllum toxicity: a report of a fatal case and a review of the literature

J Toxicol Clin Toxicol. 1982 Mar;19(1):35-44. doi: 10.3109/15563658208990364.


A 59-yr-old male ingested 10 g of podophyllum in a fatal suicide attempt. Previously unreported nuclear and cytoplasmic changes were observed in circulating leukocytes. Symptoms did not occur until 10 h after ingestion with loss of reflexes, coma, and a marked lactic acidosis. Despite hemoperfusion, the patient expired 39 h after ingestion. The literature on podophyllum toxicity is reviewed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Child, Preschool
  • Female
  • Hemoperfusion
  • Humans
  • Male
  • Middle Aged
  • Podophyllin / metabolism
  • Podophyllin / poisoning*
  • Suicide


  • Podophyllin