Evidence for the presence of circulating immune complexes in serum and C3b and C3d on red cells of kala-azar patients

Trans R Soc Trop Med Hyg. 1982;76(6):793-6. doi: 10.1016/0035-9203(82)90110-9.


The presence of immune complexes in serum, and the existence of immunoglobulin and complement on the surface of red blood cells of kala-azar patients was studied. IgG, C3b and C3d were detected on the surface of red cells of some of the patients by a direct anti-globulin test. PEG precipitation and platelet aggregation techniques demonstrated the existence of immune complexes in the sera of all nine patients examined. Both Leishmania antigen and anti-Leishmania antibody were detected in the PEG-precipitated immune complexes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigen-Antibody Complex / analysis*
  • Child
  • Child, Preschool
  • Complement C3 / analysis*
  • Complement C3b / analysis*
  • Complement C3d
  • Coombs Test
  • Erythrocytes / immunology*
  • Fluorescent Antibody Technique
  • Humans
  • Immunoglobulin G / analysis
  • Immunoglobulin M / analysis
  • Leishmania / immunology
  • Leishmaniasis, Visceral / immunology*
  • Platelet Aggregation


  • Antigen-Antibody Complex
  • Complement C3
  • Immunoglobulin G
  • Immunoglobulin M
  • Complement C3b
  • Complement C3d