Trazodone hydrochloride: a wide spectrum antidepressant with a unique pharmacological profile. A review of its neurochemical effects, pharmacology, clinical efficacy, and toxicology

Pharmacotherapy. 1982 Sep-Oct;2(5):255-65. doi: 10.1002/j.1875-9114.1982.tb03193.x.


Trazodone is a new antidepressant agent that was recently introduced in the United States. It has a unique pharmacological profile that is not typical of either tricyclic or monoamine oxidase inhibitor antidepressants. As such it represents a new class of antidepressant drugs. The efficacy of trazodone has been clearly established in comparative studies with imipramine and amitriptyline. Major depression is the principal indication for its use, but good results have been shown in a wide variety of depressive subtypes. Of particular importance is the low frequency of adverse reactions seen with this drug.

Publication types

  • Clinical Trial
  • Review

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Brain Chemistry / drug effects
  • Clinical Trials as Topic
  • Depressive Disorder / drug therapy
  • Depressive Disorder / metabolism
  • Drug Evaluation
  • Humans
  • Piperazines / pharmacology*
  • Trazodone / metabolism
  • Trazodone / pharmacology*
  • Trazodone / therapeutic use
  • Trazodone / toxicity


  • Piperazines
  • Trazodone