Loperamide modifies Escherichia coli, heat-stable enterotoxin-induced intestinal secretion

J Pediatr Gastroenterol Nutr. 1982;1(4):583-6. doi: 10.1097/00005176-198212000-00023.


We have shown previously that loperamide, an opiate analogue, inhibits cholera-toxin- and prostaglandin E2-induced secretion in the rat small intestine. In these studies loperamide modified secretion induced by partially purified Escherichia coli, heat-stable enterotoxin in infant mice. The drug was effective whether administered before or after established secretion. These experiments provide further suggestive evidence that loperamide has a broad spectrum of antisecretory activity.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Clinical Trials as Topic
  • Enterotoxins / antagonists & inhibitors*
  • Escherichia coli / drug effects*
  • Hot Temperature
  • Intestinal Mucosa / metabolism*
  • Loperamide / pharmacology*
  • Mice
  • Piperidines / pharmacology*
  • Random Allocation
  • Time Factors


  • Enterotoxins
  • Piperidines
  • Loperamide