Ineffectiveness of imipramine in children who fail to respond to methylphenidate

J Autism Dev Disord. 1980 Jun;10(2):129-37. doi: 10.1007/BF02408464.


Ten hyperactive children who had failed to respond to methylphenidate were treated with imipramine in a placebo-controlled, crossover design. No significant drug effects were obtained either on parent and teacher ratings of the child's behavior or on the child's performance in a laboratory measure of sustained attention. Findings suggest that imipramine has limited clinical usefulness in the treatment of hyperactive children who fail to respond to methylphenidate.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aggression / drug effects
  • Attention / drug effects
  • Attention Deficit Disorder with Hyperactivity / drug therapy*
  • Attention Deficit Disorder with Hyperactivity / psychology
  • Child
  • Clinical Trials as Topic
  • Double-Blind Method
  • Humans
  • Imipramine / therapeutic use*
  • Methylphenidate / therapeutic use*
  • Motor Activity / drug effects
  • Psychological Tests
  • Random Allocation


  • Methylphenidate
  • Imipramine