Solubility of carbon dioxide in lipid bilayer membranes and organic solvents

Biochim Biophys Acta. 1980 Mar 13;596(3):352-8. doi: 10.1016/0005-2736(80)90122-4.


Partition coefficients of carbon dioxide into lipid bilayers (liposomes) and organic solvents were measured as a function of temperature. The molar partition coefficient of CO2 into liposomes of egg lecithin at 25 degrees C was 0.95 (ml CO2/ml lipid)/(ml CO2/ml saline). The addition of an equimolar amount of cholesterol to the egg lecithin decreased the partition coefficient by about 25%. The partition coefficients for CO2 into liposomes at 25 degrees C were lower than the partition coefficients into octanol (1.3), hexadecane (1.5) and olive oil (1.7). The results are discussed in terms of the solubility-diffusion model of non-electrolyte transport through lipid bilayer membranes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Carbon Dioxide*
  • Cholesterol
  • Lipid Bilayers*
  • Liposomes
  • Permeability
  • Phosphatidylcholines
  • Solubility
  • Solvents*
  • Temperature


  • Lipid Bilayers
  • Liposomes
  • Phosphatidylcholines
  • Solvents
  • Carbon Dioxide
  • Cholesterol