Quintuplet pregnancies

Eur J Obstet Gynecol Reprod Biol. 1980 May;10(4):257-68. doi: 10.1016/0028-2243(80)90006-4.


Five quintuplet pregnancies, following induction of ovulation with clomiphene and HMG-HCG, are the subject of this communication. In 3 women, pregnancy was associated with ovarian overstimulation, and two patients required emergency surgery because of torsion of an ovarian cyst. Two women aborted in mid-trimester, while the other 3 delivered by cesarean section at 33-35 wk gestation. 15 babies were born, weighing 700-2200 g. 8 infants suffered from respiratory distress syndrome and 5 babies were born with correctable malformations. 13 newborns survived, and all are mentally and physically well-developed. Four of the 5 women conceived again. The management of the patients during multiple gestation and the outcome of pregnancy are discussed.

MeSH terms

  • Clomiphene / adverse effects
  • Clomiphene / therapeutic use
  • Female
  • Gonadotropins, Pituitary* / adverse effects
  • Gonadotropins, Pituitary* / therapeutic use
  • Humans
  • Infant, Newborn
  • Infant, Newborn, Diseases / etiology
  • Menotropins / adverse effects
  • Menotropins / therapeutic use
  • Ovulation / drug effects
  • Ovulation Induction*
  • Pregnancy
  • Pregnancy Maintenance
  • Pregnancy, Multiple*
  • Quintuplets*
  • Sex Ratio


  • Gonadotropins, Pituitary
  • Clomiphene
  • Menotropins