Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977;32(3):175-81.
doi: 10.1111/j.1423-0410.1977.tb00622.x.

Development of an Intravenous Gamma-Globulin With Fc Activities. I. Preparation and Characterization of S-sulfonated Human Gamma-Globulin

Development of an Intravenous Gamma-Globulin With Fc Activities. I. Preparation and Characterization of S-sulfonated Human Gamma-Globulin

Y Masuho et al. Vox Sang. .

Abstract

S-sulfonated gamma-globulin (S-GG) was prepared by treating gamma-globulin with sulfite and tetrathionate ions. About four interchain disulfide bonds were selectively cleaved to give S-sulfonate groups. Although the above treatment strongly suppresses anticomplementary activity and nonspecific skin reactivity, the resulting S-GG retains high antibody activity. Furthermore, S-GG was found to maintain satisfactory levels for prolonged periods in vivo. The physicochemical and antigenic analyses of S-GG suggest that the S-sulfonation induces structural modification only at restricted sites.

Similar articles

See all similar articles

Cited by 9 articles

See all "Cited by" articles

LinkOut - more resources

Feedback