Metastatic choroidal melanoma

Am J Ophthalmol. 1978 Jul;86(1):76-80. doi: 10.1016/0002-9394(78)90018-1.


We studied the metastatic pattern of 41 patients initially referred with a primary choroidal melanoma who later developed widespread disease. In the order of frequency, the most common sites of metastatic involvement were the liver (56%), subcutaneous tissue (36.5%), and bone (7%). Whereas the median interval between enucleation and the onset of metastatic disease was approximately four years, in rare cases, metastases were diagnosed concurrently with a primary choroidal melanoma. Since patients with choroidal melanomas usually survive less than one year after the development of widespread disease, a metastatic examination should be done in all patients with pigmented choroidal tumors both before and after ocular therapy. From the data obtained in this and other studies on metastatic melanoma, a reasonable basic metastatic examination for choroidal melanoma patients should include a serum lactic dehydrogenase, a serum alkaline phosphatase, a routine chest X-ray, and a general physical examination.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Bone Neoplasms / diagnosis
  • Choroid Neoplasms / diagnosis*
  • Choroid Neoplasms / mortality
  • Choroid Neoplasms / pathology
  • Female
  • Humans
  • Liver Neoplasms / diagnosis
  • Male
  • Melanoma / diagnosis*
  • Melanoma / mortality
  • Melanoma / pathology
  • Middle Aged
  • Neoplasm Metastasis / diagnosis*
  • Neoplasm Metastasis / mortality
  • Soft Tissue Neoplasms / diagnosis