In vivo and in vitro antimicrobial activity of silver sulfadiazine and cerium nitrate

Surg Gynecol Obstet. 1980 Aug;151(2):232-6.


The antimicrobial activity of cerium nitrate and silver sulfadiazine was assessed in vitro and in vivo using Pseudomonas aeruginosa. In vitro, the activity of silver sulfadiazine was significantly greater than that of cerium nitrate. Synergism between silver sulfadiazine and cerium nitrate was observed in water or saline solution suspensions, but not in broth. In vivo, cerium nitrate offered no therapeutic benefit in reducing wound infection in contaminated wounds. Treatment of similar wounds with silver sulfadiazine resulted in a significant decrease in wound infection and in the level of viable bacteria when compared with that for untreated controls. The addition of cerium nitrate to silver sulfadiazine in aqueous soultion reduced the therapeutic benefit of silver sulfadiazine.

MeSH terms

  • Animals
  • Bacterial Infections / drug therapy
  • Cerium / pharmacology*
  • Cerium / therapeutic use
  • Drug Synergism
  • Guinea Pigs
  • In Vitro Techniques
  • Male
  • Microbial Sensitivity Tests
  • Pseudomonas aeruginosa / drug effects*
  • Silver Sulfadiazine / pharmacology*
  • Silver Sulfadiazine / therapeutic use
  • Sulfadiazine / pharmacology*
  • Wound Infection / drug therapy


  • Sulfadiazine
  • Cerium
  • Silver Sulfadiazine