3-Trehalosamine, a new disaccharide antibiotic

J Antibiot (Tokyo). 1980 Jul;33(7):690-4. doi: 10.7164/antibiotics.33.690.

Abstract

3-Amino-3-deoxy-alpha-D-glucopyranosyl-alpha-D-glucopyranoside (alpha, alpha--3-trehalosamine) was isolated from a culture of Nocardiopsis trehalosei sp. nov. (NRRL 12026). The structure was determined using a combination of spectroscopic techniques on derivatives of the component sugars, especially gas chromatography-mass spectrometry. The compound exhibited antibiotic activity against Gram-positive organisms at levels similar to what was found for the 2- and 4-trehalosamines.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / analysis
  • Anti-Bacterial Agents / biosynthesis*
  • Anti-Bacterial Agents / pharmacology
  • Bacillus subtilis / drug effects
  • Bacteria / drug effects
  • Chemical Phenomena
  • Chemistry
  • Disaccharides / biosynthesis*
  • Fermentation
  • Mice
  • Pneumonia, Pneumococcal / drug therapy
  • Trehalose / analogs & derivatives
  • Trehalose / analysis
  • Trehalose / biosynthesis*
  • Trehalose / pharmacology

Substances

  • Anti-Bacterial Agents
  • Disaccharides
  • 3-trehalosamine
  • Trehalose