Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

Nature. 1980 Aug 14;286(5774):676-83. doi: 10.1038/286676a0.


At least two types of somatic recombination are necessary for the generation of a complete immunoglobulin gamma 2b gene from germ-line DNA sequences. The first type of recombination consists of the assembly of three separate DNA segments, each encoding a different part of the variable region. The second type of recombination replaces the exons coding for the constant region of the mu chain with those coding for the same region of the gamma 2b chain. The DNA sequencing studies suggest that the two types of recombination operate by different mechanisms.

MeSH terms

  • Animals
  • Base Sequence
  • Genes
  • Immunoglobulin Constant Regions / genetics
  • Immunoglobulin Heavy Chains / genetics*
  • Immunoglobulin Variable Region / genetics
  • Immunoglobulin gamma-Chains / genetics
  • Immunoglobulin mu-Chains / genetics
  • Mice
  • Myeloma Proteins / genetics
  • Nucleic Acid Precursors / genetics
  • Recombination, Genetic*


  • Immunoglobulin Constant Regions
  • Immunoglobulin Heavy Chains
  • Immunoglobulin Variable Region
  • Immunoglobulin gamma-Chains
  • Immunoglobulin mu-Chains
  • Myeloma Proteins
  • Nucleic Acid Precursors

Associated data

  • GENBANK/J00440
  • GENBANK/J00442
  • GENBANK/J00460
  • GENBANK/J00480
  • GENBANK/J00481
  • GENBANK/J00491
  • GENBANK/J00492
  • GENBANK/V01524