The 5' ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I

Nature. 1980 Aug 28;286(5776):854-60. doi: 10.1038/286854a0.


Many specific sites in Drosophila chromatin are hypersensitive to DNase I. The positions of such sites were mapped along the regions of the genome coding for two heat shock proteins. Such sites lie at the 5' ends of heat shock genes and may function as elements for recognition by molecules which regulate gene activity.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Cells, Cultured
  • Chromatin / ultrastructure*
  • Chromosome Mapping
  • Deoxyribonucleases / metabolism*
  • Drosophila melanogaster / embryology
  • Drosophila melanogaster / genetics*
  • Genes
  • Hot Temperature*
  • Kinetics
  • Nucleosomes / ultrastructure


  • Chromatin
  • Nucleosomes
  • Deoxyribonucleases