Enterocolitis is lesser known complication of gold therapy. Two cases of fulminant colitis, complicating chrysotherapy for rheumatoid arthritis are described. One patient required colectomy, whereas the other responded to intensive medical treatment. Colonic biopsies demonstrated extensive ulcerations, diffuse edema, multiple hemorrhages and a dense mononuclear cell infiltrate. Our experience emphasizes the paramount importance of early recognition and treatment of this serious complication.