Abstract
Low-molecular-weight (< 1500 daltons) peptides with inhibin activity have been isolated from sheep testes and ovaries by simple gel filtration. These peptides were capable of inhibiting the ovarian weight increase in hCG-primed immature female mice and also of suppressing the post-castration rise of serum FSH levels in adult male rats, suggesting similarities in their biological properties. Both testicular and ovarian inhibin were typsin sensitive and heat stable at 100 degrees C for 30 min and were shown to act by interfering with the production of a hypothetical FSH-RH.
MeSH terms
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Animals
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Female
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Follicle Stimulating Hormone / metabolism
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Gonadotropin-Releasing Hormone / antagonists & inhibitors*
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Gonadotropin-Releasing Hormone / isolation & purification
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Gonadotropin-Releasing Hormone / metabolism
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Gonadotropin-Releasing Hormone / pharmacology
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Hormones / pharmacology
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Inhibins
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Kidney / analysis
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Liver / analysis
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Luteinizing Hormone / metabolism
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Male
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Ovary / analysis*
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Proteins / isolation & purification*
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Proteins / pharmacology
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Sheep
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Testicular Hormones / isolation & purification*
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Testicular Hormones / pharmacology
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Testis / analysis*
Substances
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Hormones
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Proteins
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Testicular Hormones
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Gonadotropin-Releasing Hormone
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Inhibins
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Luteinizing Hormone
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Follicle Stimulating Hormone