The sequence at the 3' terminus of mouse immunoglobulin secreted mu chain messenger RNA determined from cloned cDNA

Nucleic Acids Res. 1980 Feb 25;8(4):703-13.

Abstract

The 3' terminal nucleotide sequence of two clones containing DNA complementary to mu chain mRNA of IgM-secreting cells has been determined. The sequence shows a termination codon (UGA) adjacent to the terminal tyrosine codon for the secreted protein and a 3' non-coding region of at least 106 bases. The primary translation product of this mu chain mRNA seems to terminate at the tyrosine of the secreted protein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Cloning, Molecular
  • Codon
  • DNA, Recombinant*
  • Immunoglobulin Heavy Chains / genetics*
  • Immunoglobulin M / genetics*
  • Immunoglobulin mu-Chains / genetics*
  • Mice
  • Peptide Chain Termination, Translational
  • RNA, Messenger / genetics*

Substances

  • Codon
  • DNA, Recombinant
  • Immunoglobulin Heavy Chains
  • Immunoglobulin M
  • Immunoglobulin mu-Chains
  • RNA, Messenger

Associated data

  • GENBANK/J00443