A clinical trial of hyperalimentation in children with metastatic malignancies

Med Pediatr Oncol. 1980;8(1):63-73. doi: 10.1002/mpo.2950080110.


In a controlled, randomized prospective clinical trial the utility of intravenous hyperalimentation (IVH) in the administration of and tolerance to chemotherapy was tested. The conclusions reached were 1) IVH is safe with a tolerable infection rate; 2) infectious complications correlate significantly with the nutritional status of the patient, with the presence of IVH being only a secondary factor; 3) IVH may be used to rehabilitate patients nutritionally, even those on intensive chemotherapy; 4) the ability to deliver chemotherapy to patients seems to be improved by IVH, especially in malnourished patients in a late stage of disease.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antineoplastic Agents / administration & dosage
  • Child
  • Child Nutritional Physiological Phenomena
  • Clinical Trials as Topic
  • Drug Therapy, Combination
  • Female
  • Humans
  • Infections / etiology
  • Male
  • Neoplasm Metastasis / therapy*
  • Parenteral Nutrition* / adverse effects
  • Parenteral Nutrition, Total* / adverse effects
  • Prospective Studies


  • Antineoplastic Agents