Over-estimation of glomerular filtration rate by single injection [51Cr]EDTA plasma clearance determination in patients with ascites

Scand J Clin Lab Invest. 1980 May;40(3):279-84. doi: 10.3109/00365518009095579.


The total plasma (Clt) and the renal plasma (Clr) clearances of [51Cr]EDTA were determined simultaneously in nine patients with ascites due to liver cirrhosis. Clt (mean 78 ml/min, range 34-115 ml/min) was significantly higher than Clr (mean 52 ml/min, range 13-96 ml/min, P < 0.005). The ascitic fluid-plasma activity ratio of [51Cr]EDTA increased throughout the investigation period (5h). The results suggest that [51Cr]EDTA equilibrates slowly with the peritoneal space which indicates that Clt will over-estimate the glomerular filtration rate by approximately 20 ml/min in patients with ascites. To assess glomerular filtration rate in presence of ascites, the renal plasma clearance of [51Cr]EDTA should be used instead of the total plasma clearance.

MeSH terms

  • Adult
  • Age Factors
  • Ascites / complications
  • Ascites / metabolism*
  • Body Weight
  • Chromium Radioisotopes
  • Creatinine / blood
  • Creatinine / metabolism
  • Edetic Acid / blood
  • Edetic Acid / metabolism*
  • Female
  • Glomerular Filtration Rate*
  • Humans
  • Kidney / metabolism
  • Liver Cirrhosis / complications
  • Male
  • Metabolic Clearance Rate
  • Middle Aged
  • Sex Factors


  • Chromium Radioisotopes
  • Edetic Acid
  • Creatinine