The use of human menopausal and chorionic gonadotropins for induction of ovulation. Sixteen years' experience at the Sloane Hospital for Women

Am J Obstet Gynecol. 1980 Dec 1;138(7 Pt 1):801-7. doi: 10.1016/s0002-9378(16)32740-5.


Gonadotropin therapy for anovulation is highly successful: 58.6% of treated patients conceive. Better results are achieved in patients with galactorrhea-amenorrhea (77.1%) and hypogonadotropic hypogonadism (63.3%) than in patients with normal gonadotropin levels (45.4%). The spontaneous abortion rate (27.5%) is somewhat higher than that in spontaneous pregnancies. The multiple pregnancy rate is 31% and was slightly lower in cycles with preovulatory estrogen levels in the physiologic range. In patients treated with human menopausal and chorionic gonadotropins for 7 to 9 days per cycle, the multiple pregnancy rate is considerably less (12.9%) than in patients with longer treatment. The efficacy of treatment does not diminish with repeat-treatment cycles.

MeSH terms

  • Amenorrhea / drug therapy
  • Chorionic Gonadotropin / therapeutic use*
  • Dose-Response Relationship, Drug
  • Estrogens / blood
  • Female
  • Galactorrhea / drug therapy
  • Humans
  • Infant, Newborn
  • Infertility, Female / drug therapy*
  • Menotropins / therapeutic use*
  • Ovulation Induction*
  • Pregnancy
  • Pregnancy, Multiple
  • Time Factors


  • Chorionic Gonadotropin
  • Estrogens
  • Menotropins