Difference in nitroglycerin dose-response in the venous and arterial beds

Eur J Clin Pharmacol. 1980 Nov;18(6):455-60. doi: 10.1007/BF00874655.

Abstract

In twelve healthy volunteers given nitroglycerin sublingually (1.6 mg) or epicutaneously (12 mg), venous distensibility was found to be maximal, even at low plasma concentrations (less than 0.2 ng/ml); there was no further change with increasing concentrations. Peripheral arterial resistance, on the other hand, decreased progressively with rising plasma concentrations and no distinct plateau was demonstrable, even at the highest plasma concentration measured (greater than 2.0 ng/ml).

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Arteries / physiology*
  • Dose-Response Relationship, Drug
  • Humans
  • Male
  • Mathematics
  • Nitroglycerin / blood
  • Nitroglycerin / pharmacology*
  • Vascular Resistance / drug effects*
  • Veins / physiology*

Substances

  • Nitroglycerin