Brief social isolation, pain responsiveness, and morphine analgesia in young rats

Psychopharmacology (Berl). 1980;72(1):111-2. doi: 10.1007/BF00433816.

Abstract

Vocalizations induced by brief tail-shock were measured in young rats that were either socially or individually housed. A single day of isolation increased tail-shock-induced vocalizations, and in animals isolated 3--4 days, morphine (4 mg/kg) was less effective in reducing vocalizations than in socially housed animals. The data suggest that social contact can sustain endogenous analgesic processes in the body.

MeSH terms

  • Analgesia
  • Animals
  • Electroshock
  • Female
  • Male
  • Morphine / pharmacology*
  • Nociceptors / drug effects
  • Pain* / psychology
  • Rats
  • Social Isolation*
  • Tail
  • Vocalization, Animal / drug effects

Substances

  • Morphine