Occupational asthma due to inhalation of chloramine-T. I. Clinical observations and inhalation-provocation studies

Int Arch Allergy Appl Immunol. 1981;64(4):422-7. doi: 10.1159/000232722.


Respiratory symptoms developed in 5 patients who were exposed to chloramine-T, a potent disinfectant used in cleaning butcheries, kitchens, and operating theaters. Skin tests, performed in 4 patients, showed an immediate type of wheal and flare reaction followed by a late-type infiltrative reaction. In 3 patients, inhalation tests with chloramine-T were done. 1 patient showed asthmatic bronchial obstruction, immediately after inhalation, followed by a late-type asthmatic reaction after some hours. 2 patients only exhibited late-type reactions, 4-8 h after challenge. The late bronchial response lasted for several hours or even days and was accompanied by leukocytosis in all 3 patients and a slight fever in 1 patient. No evidence of alveolar involvement appeared. Pre-challenge inhalation of cromoglycate in 1 patient ameliorated the late response considerably.

MeSH terms

  • Administration, Intranasal
  • Adult
  • Asthma / diagnosis
  • Asthma / drug therapy
  • Asthma / etiology*
  • Bronchial Provocation Tests*
  • Chloramines / adverse effects*
  • Cromolyn Sodium / therapeutic use
  • Female
  • Forced Expiratory Volume
  • Humans
  • Male
  • Occupational Diseases / diagnosis
  • Occupational Diseases / etiology*
  • Radiography, Thoracic
  • Respiratory Function Tests
  • Skin Tests
  • Time Factors
  • Tosyl Compounds*


  • Chloramines
  • Tosyl Compounds
  • chloramine-T
  • Cromolyn Sodium